This one might not be right for everybody, but for many, it might be worth considering investing in a mini-split HVAC system. These little systems don't require ducting, and they can cut cooling costs by as much as 30% percent. However, they do sometimes require a pretty sizable upfront investment. Still, they're easy to install compared to traditional A/C units and can save you a ton of money in the long run.
You can also cool or heat around four rooms with most mini splits, meaning this might be perfect for most people. They're also a better choice than window units as they cool and heat up to 40% more efficiently.