Missouri is right on the border of the South and the Midwest, so it has all of the benefits of both, but it also has all of the downsides. There have been a lot of large factory closings in the state recently. Missouri also suffers from the incredibly hot and humid summers typical in Southern states and the harsh winters you find in the Midwest. Much of the state is rural.
It's filled with a lot of beautiful places, but good-paying jobs are hard to come by in more rural areas. Missouri is a mixed bag that hasn't always attracted a lot of people from outside.